To develop a cartilage repair hydrogel
Israel Regentis Biomaterials has introduced an innovative hydrogel designed for cartilage repair. This advanced material is made from a combination of polyvinyl alcohol and a specific amount of fibrinogen, making it a biodegradable synthetic substance. Once injected into the site of a cartilage injury, the hydrogel can be shaped as needed and activated by the release of fibrinogen, promoting natural tissue integration. The hydrogel supports the regeneration of cartilage cells, which then seamlessly merge with the surrounding tissue.
According to Yaya Hill Taur, the company's CEO, the key to successful development lies in synchronizing tissue regeneration with the rate of biodegradation. Many existing materials fail because they degrade too quickly, leaving little time for cell growth. The hydrogel developed by Israel Regentis offers precise control over this process by adjusting the ratio of polyvinyl alcohol to fibrinogen. When the polyvinyl alcohol content is higher, the degradation slows down, allowing more time for the cartilage to heal and regenerate properly.
Knee cartilage is a transparent, soft tissue that plays a crucial role in joint lubrication, shock absorption, and weight distribution. However, once damaged, it has limited regenerative capacity due to poor blood supply. The global market for cartilage regeneration is valued at $1.6 billion, with around 400,000 patients in the U.S. and Europe awaiting treatment. This highlights the urgent need for more effective solutions.
The technology is currently undergoing clinical trials and shows promise not only for cartilage repair but also for bone and spinal cord regeneration. As research progresses, this hydrogel could revolutionize the field of regenerative medicine, offering new hope to patients suffering from various tissue injuries.
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